It seems that there are some problems displaying PDFs on macOS Sierra 10.12.2 And it is not a problem that comes again, it is a failure that has been located in the Apple operating system for a long time and that seems to be not solved. Apple constantly releases updates to its operating systems but there are details such as in this case of managing PDF files that do not seem to find a solution in these new updates.
This is the case of Fujitsu and its ScanScap users with a bug in PDF handling in scanner solved as PDFKit problem in macOS 10.12 or problems found by DEVONthink developer Christian Grunenberg, which warn of the problems with documents in this PDF format. It seems that the compatibility that Cupertino wants to give it with the iOS and macOS framework, would be causing some problems. In addition, Adam C. Engst himself at TidBITS warns us in this article about it.
Now the co-author of Take Control of Preview, Adam Engst explains that it is true that Apple added a solution to the problem in the version prior to the current 10.12.1, but right now problems with PDF and preview reappear in current version:
I have to advise macOS Sierra users to avoid using Preview to edit PDF documents until Apple fixes these glitches. If editing a PDF in Preview is unavoidable, be sure to only work on one copy of the file and keep the original PDF.
It is possible that if you can read a PDF document without any problem in Preview, but when you have to edit it, it could "Crash" automatically and render the document unusable for other applications, For this reason, the advice to keep a copy of the original document and not lose everything or use a third-party application that uses its own PDF libraries for these editions since they are the safest option today.