If we have recently updated our system to the latest version 10.8 or to one of the minor updates such as version 10.8.3, it is possible that part of our applications they have not taken the change so well as we would like so that either when executing them, unexpected closings occur or they just hang, so it is likely that something has not been updated correctly.
These failures occur on rare occasions and in a way we could almost say that they were random, however they share a common link between all the affected applications and that is that all are 32 bit programs.
To try to solve this type of failure that always brings us upside down, the best thing is start the system in safe mode, so we will restart the Mac and hold down the Shift key until the boot begins. With this simple step, in most cases these application closures will be solved when loading, since some maintenance routines are carried out while the system loads in this mode. Among all these routines is the one that will help solve this problem:
A safe boot clears the shared cache dynamic loader in (/ var / db / dyld /). A problem cache can cause a blue screen at startup, especially after a software update. On normal restart, this cache is re-created.
If we had a problem booting into safe mode, we could try third-party apps to try to solve it. Free and effective applications such as OnyX, in which system maintenance will be performed and we can probably fix this fault as well.
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Source - Cnet